Hello and thanks for the suggestions, I’ll give them a try and let you know.

The monitors and PC are plugged into different outlets.
I’m running 4 x 1080p off the MST Hub plus 1 x 1080p off the HDMI output directly off the card.

Here’s the information on video card:
XFX Double D Radeon R9 270X DirectX 11.2 R9-270X-CDFC 2GB 256-Bit GDDR5 PCI Express 3.0 x16 HDCP Ready Video Card

 BIOS Version/Date American Megatrends Inc. P1.30, 5/26/2014 (Will try updating to latest)

Catalyst version 14.9 

This is driving me nuts!

Regards,

Steve