Hi Roberto,
Unfortunately the Displaylink chipset does not support color calibration functionality, therefore this is normally best when the monitor is attached directly to the GPU source or a dedicated graphics card. 
In this case the best choice for you is to use the dedicated D-Sub on the monitor with the D-Sub on your notebook.
If you choose to have a USB graphics instead, I will recommend to use the USB to DP 1600p version or the 4K version and use an external calibration tool such as the Spyder4 etc.
Check with Eizo if your display comes factory calibrated, if it is calibrated then you can choose either the D-Sub or the USB Graphics solution.