Hey Clubbie,
It's just a driver update, so the solution will be installing the new driver once it's released (and the release notes mention this fix). :P
After the previous email I replied with the MST hubs I tested and the reason why I thought this was driver related, looks like I was right. :)
Part of my email:
I personally think it’s the driver who is limiting the output to one screen per displayport connection.
In the past I had sort of this problem with my Fury X. At first I used the Club3D CSV-5400 to connect four screens to one connection and the other two screens directly to the card. This all worked fine until a driver update (don’t remember which one). After that driver update the card would only see three screens connected to the hub; no matter what I tried. The solution back then was just buying another MST hub and only connect three screens per hub. So I know the driver can limit the amount of screens supported per displayport connection.