Freesync or not?
I don’t think so.
Tested: CAC-1336, Radeon RX 580, Acer XV273K.
Windows 10: Freesync can be enabled from direct DisplayPort connection but not from HDMI 2.0 port and CAC-1336.
macOS 12.4: I think a newer GPU is require for VRR.
At least HDR works.
I don’t have a GPU with a HDMI 2.1 port.