If the monitor does not have a USB-C port, then you need one cable for video (DisplayPort or HDMI) and another cable for data (USB 3.x).
If you still want only one cable to your laptop, then you need a USB-C or Thunderbolt dock. Then you can connect the two cables from the display to the dock and one cable from the dock to the laptop.
If your laptop supports Thunderbolt 3/4 or USB4, then a Thunderbolt dock would be the best dock option for max video and a data bandwidth.
A USB-C dock may also work. If the display is 4K 60Hz, then you’ll want a USB-C dock that does not support USB 3.x so that all the bandwidth can be for video. CableMatters has some USB-C docks that can do that (they support USB 2.0 only).
A USB-C dock that supports USB 3.x will be limited to 4K 30Hz unless the dock and laptop and display supports DisplayPort 1.4 (HBR3). If the display doesn’t support HBR3, then an MST hub can convert two lanes of HBR3 to four lanes of HBR2. Some docks have a MST Hub built in to support multiple displays.
The CalDigit SOHO is a simple USB-C dock supporting USB 10 Gbps and DisplayPort 1.4 with DisplayPort 1.4 MST Hub which also support DSC (all DisplayPort 1.4 MST hubs should support DSC – it might require a firmware update though). If the laptop has a Navi or RTX or Intel 11th gen graphics then DSC can be used to effectively double the bandwidth – the MST Hub can decompress DSC input for displays that don’t support DSC.